New Thoughts about some old medicines
One of the curious societal circumstances is that poisonous drugs are allowed to be sold over the counter in an unregulated fashion and nontoxic ones are restricted. I don't understand why this is so, only that it is so.
One of the oldest medicines in use is aspirin. Salicylic acid was initially extracted from willow bark ( from latin salix=willow tree) and subsequently made synthetically.
It is a phenolic phytohormone which acts throughout the plant to induce defensive responses in the plant to pathogens. Volatile methyl-salicylate is naturally produced by the willow when stressed and will induce a similar response in nearby plants when they are exposed to the vapours.
Willow was used as a herbal remedy for fevers, pain, acne and arthritis. It has an assortment of side effects like urticaria ( rash) deafness, metabolic acidosis and Reyes syndrome.
Continuing applications of Salicylic acid are for acne, as a treatment of dandruff and for dissolving calluses as an exfoliative (removes dead skin).
In 1897 the Bayer company modified Salicylate by acetylation and "Aspirin" (acetylsalicylic acid ) was born. This was aggressively marketed by Bayer even though it had been first synthesized by the French chemist Gerhardt in 1853.
It was better tolerated that the simple salicylate compound and had additional effects. It is estimated that currently 40,000 tonnes are consumed annually!
(PS: as partial reparations extracted from Germany after WWI Bayer's patents were invalidated by seizure and dispersed to the conquerors . Aspirin was one of those patents)
Bayer laboratories was a busy place and one of the things they were working on in 1865 was a synthetic blue dye to replace the expensive and uncommon plant derived blue indigo dyes.
These indigo dyes were rare and expensive enough to be called "blue gold" in ancient India. The natural dyes are a metabolite of the ring/cyclic amino acid Tryptophan, made by the specific fermentation of certain plants in big piles by the Indians to create the blue color.
The destructive distillation of indigo in 1826 produced aniline, a toxic ring compound related to phenol and benzene. This chemical is used for many chemical reactions including the production of polyurethanes and many dyes in the "colourant industry".
A cheap and reliable aniline purple dye was made accidentally by 18 yr old William Henry Perkin in england who was attempting to make quinine in chemistry class. Because He was a student and not employed by a chemical firm, he was able to patent the compound and build a fortune in the dye works.
Later variations of this compound were used for "ditto" machines to print those fragrant blue copies that many of us remember. It was probably carcinogenic too!
While experimenting with aniline, the bayer company made a white powder from coal- tar derived aniline which they called phenacetin or acetanilide.
Since it was colorless and not useful as a dye, they wondered what they could do with it to make money........ So they gave it to sick people!
It would block fever and people who took it would have less pain complaints but a significant number of them would unfortunately turn blue and die. The compound is a general metabolic poison and will often induce methemoglobinemia or even wide spread acute hemolysis.
Despite those little problems it was widely marketed as APC (aspirin-phenacetin-caffiene) until being withdrawn from the market in 1983 because of cancer causing and kidney killing effects (renal papillary necrosis). If that doesn't kill you right away , it caused cancer of the kidneys and urological tract (likely other cancers as well).
A metabolite of phenacetin was observed, then synthesized and has been independently marketed since 1887, it is called acetaminophen or paracetamol or APAP or Tylenol. It is the first direct metabolite of phenacetin in people.
It was mixed with various other compounds most notably with codeine to limit the "abuse " of codeine and make those who took too much codeine ill! (curiously codeine and the other narcotics are notably NON_TOXIC in comparison to acetaminophen).
How does such a regulatory mind work that would add a poison to a non-toxic medicine purposely to make people sick?
For discussion, codeine is a natural narcotic chemical derived from the poppy. Other natural narcotics are morphine and theobaine . Morphine was isolated from the poppy in 1804 and it's structure as a complex polycyclic was not defined till much later.
Chemically Modified semi-synthetic) narcotics in common use today are hydrocodone and oxycodone. When they are mixed with acetaminophen/APAP they are called lortab or percocet respectively.
These are very common medications and amount to huge $ in the "pharmaceutical " trade.
So what is the problem You may ask? Despite increasing irrefutable data about the toxicity of acetaminophen , it is still being taken like candy over the counter. It is in many witches-brew compounds and is an adulterant in narcotic prescriptions (such as percocet, tylenol- codiene , and lortab).
Acetaminophen is a leading cause of liver disease in the world through acute and chronic mechanisms! Acetaminophen associated Kidney disease is well known and the increase in cancers of all types is highly suspect. There is evidence that Alzheimer's disease is linked with intake of acetaminophen .
Taking tylenol with narcotics is particularly bad because the less poisonous / more natural narcotics are better suited to our metabolism and get preferential attention by our liver cytochrome p450 enzymes.
When this happens, acetaminophen is shunted to a secondary pathway of N-hydroxylation to form the toxic alkylating metabolite NAPQI which irreversibly attacks glutathione and other important compounds in our bodies ( like our DNA and critical proteins).
Some people have metabolisms which preferentially produce NAPQI from acetaminophen even without having any competing compounds like the narcotics present.
Having even the smallest amount of alcohol in your system when taking acetaminophen is equally toxic. Because the liver metabolism prioritizes natural chemicals like alcohol and pushes un-natural chemicals like acetaminophen to N-hydroxylations pathways it is imperative to Avoid having any acetaminophen intake with alcohol.
When the increasing incidence of cancers of all types are noted, the wide spread ingestion of acetaminophen is very concerning. I would like to see acetaminophen banned in all forms.
Just recently, A new "black box warning" has been put on acetaminophen products stating that it may cause liver failure. It should say "does and will cause liver failure".
Tylenol is particularly poisonous to Cats! Even with very small amounts they have untreatable hemolysis (rupturing of the red blood cells) with methemoglobinemia , kidney failure , turn blue and suffocate/asphyxiate. Snakes are poisoned just like cats. Dogs suffer liver damage.
Use of acetaminophen to poison brown tree snakes in Guam has recently resurfaced but the article entirely leaves out the facts about acetaminophen toxicity in people. They neglected to mention that acetaminophen is also poisonous to fish, birds, mammals, cats, dogs and essentially all animals . Any cat which eats the dead mouse full of acetaminophen will die too.
Acetaminophen overdose is a major problem and is associated with irreversible liver damage leading to liver failure and then death over a 2 to 3 day period, There is only limited treatment possible for acetaminophen overdose and no cure for the liver failure.
I ask: " Why has poisonous acetaminophen not been removed from the market ?"
You know the answer............ big $$$$ to be lost by reduced direct sales and profits made due to the causative indirect disease .
Consider that world production of acetaminophen/paracetamol is estimated at 145,000 tonnes (metric tons) or 319,670,280 lbs or 290,000,000,000 tablets of 500 milligram dosage.
So, please avoid taking acetaminophen in any form.
Ask to have narcotic analgesics in their pure form without added poisonous APAP. Take an aspirin instead, but only now and then and never give one to your cat because it will poison them almost the same as APAP.
Choose to avoid poisonous acetaminophen in any and all forms!
Sam Wise MD
November 5, 2013
Dr. Sam Wise
Las Vegas, NV 89146
Dear Dr. Wise:
Thank you for contacting the American Center for Law and Justice (“ACLJ”). We are always happy to hear from concerned citizens and ask that you continue to support our efforts. We have received the information you sent regarding the Affordable Care Act and the fact that some people are charged more because of their higher income. To the extent that disparities in insurance prices are due to income-based subsidies and/or tax credits provided by Congress, that is a policy issue that Congress may choose to revisit in the future, but it is not unconstitutional because under Article I, Section 8 of the Constitution, Congress has broad authority to spend money to promote the “general welfare.”
We appreciate your sharing your concerns with us and hope that you will feel free to contact us in the future should the need arise. It is concerned citizens, such as you, who continue to make a difference in our communities. We encourage you to stay involved with the ACLJ and informed on important contemporary legal issues. “Jay Sekulow Live” is a daily radio program which can be heard across the country. Please refer to our website at www.aclj.org for the station closest to you. The website is also an excellent resource for news and the issues we deal with on a daily basis.
FOR LAW AND JUSTICE
my response to them
On 9/28/13 I tried accessing various sites which purported to be informative about the PPACA (obamacare) premium pricing .
Most of them didn't work but I was able to access the Kaiser Family Foundation.org site and the PPACA calculator.
What I found was highly unacceptable, so much so that on that same day I authored the following inquiry letter to the ACLU via their website
Request for an Investigation by ACLU
I am a physician board certified in Physical medicine and rehabilitation.
My practice has included many people with injuries and disabling conditions. I am very concerned about having non-prejudicial access to quality private practice healthcare and wellness for all persons. As we are perched on the edge of PPACA activation I am concerned about the high risk for fraud and abuse.
I believe that you will agree that it is wrong to charge a person more money for a product or service based on their income . The cost of an item or service is the cost and it should not change prices depending on who wanted to purchase it.
It would be especially wrong to exclude people you have a prejudice against from a transaction by telling them the price was 327% of what you would charge another person for the same service/product.
This would be especially wrong if the vendor especially disliked the poor and charged them more than people with high incomes for the same service or product to push them out of the market.
Checking on the Kaiser website http://kff.org/interactive/subsidy-calculator/ I discovered that if I listed my income at a $5000 level vs $50,000 Kaiser would charge much more for presumably the same coverage if I entered $5000 than if the value entered is $50,000!
I am still the same 60 year old nonsmoking man whether I make $5000 a year or $50,000 a year. My health risks are precisely the same.
Clearly , this is a planned systemic design which can have no explanation except prejudice, fraud, collusion and exploitation. I would bet you that any such "calculator " is biased the same way no matter where it is located within the "exchange market place"
I am contacting you because I have no trust or faith in the federal government , Kaiser or the health insurance cabal to correctly behave. Asking a pirate to not rob you will not make them stop.
They need to be punished for this scheme , ideally before they steal too much more money and denigrate/abuse any more people.
I would like you to carefully look at what I have discovered and consider what it means.
Then I would like to meet with you directly to discuss my concerns in as much detail as needed so that you will be motivated to investigate the extent of this wrongful collusion ( these are precedent RICO level infractions including the federal government itself!) and take effective actions. This scheme needs to be interrupted/ limited for the protection of our citizens at risk and those involved in the racketeering need to be punished maximally.
Sam Wise MD
On October 2,2013 I got the following response from Allison Bowmer
( firstname.lastname@example.org )
October 2, 2013
Dear Dr. Wise:
Thank you for contacting the American Civil Liberties Union of Nevada. Your letter requesting assistance has been received and reviewed by this office. Unfortunately, the ACLU of Nevada is unable to assist you or provide representation in this matter.
The ACLU of Nevada is a privately funded non-profit organization that relies heavily on the services of both volunteer interns and attorneys. Our mission is to protect and promote the Bill of Rights which places restrictions on abusive government policy. In this endeavor, we are often faced with limited resources to meet the many challenges to freedom and justice.
Due to these constraints, the ACLU of Nevada must focus on cases where the facts are not in substantial dispute and which have wide-ranging civil liberties implications. In order to use our resources most effectively, we limit our representation to those cases where our participation can benefit a large sector of people and lead to a change in law. Even among those types of cases, we can take only a small percentage of the many meritorious complaints that we receive.
Our decision in your case was based on these factors alone and not on a legal judgment of its merits. This letter should not discourage you from pursuing a resolution through other appropriate channels. Please be advised that there may be statutes of limitations or other deadlines that affect your lawsuit or grievance. To protect your rights, you may wish to consult with an attorney to find out what deadlines apply in your case.
The ACLU of Nevada cannot provide referrals to individual attorneys. However, you may wish to contact the State Bar of Nevada’s Lawyer Referral and Information Service at (800) 789-5747 for the name of a local attorney who may be able to assist you in this matter or your local legal services may provide assistance on selected matters if you fall within certain income and other guidelines. A list of possible referrals that may find you some resolution is available at: http://aclunv.org/files/Referral.pdf. Additionally, informaiton about your rights is available on our website at: http://aclunv.org/kyr.
In the future, if you have a complaint that you would like to file with the ACLU of Nevada, please visithttp://aclunv.org to fill out our on-line intake form.
We wish you the best in resolving your difficulties.
ACLU of Nevada
The response from aclunv.org vv Alison Bowmer was about what I had anticipated.
There was no specific comment on the actual concern which they called "your difficulties" , whatever that really means. It seems to me that prejudice against the poor or ill is a bill of rights issue, but what do I know? Further the letter infers that the facts were in dispute, and they are not.
When I was looking at the KFF.org site I entered several values for income and found that the premium estimates for coverage
changed significantly based upon how much $ was entered.
Note that one option they provided to me is to purchase catastrophic insurance which has a $12,700 out of pocket deductible threshold, but covers "preventive care" (?).
No estimate of premium was given for catastrophic insurance.
I would like an official Explanation how and why a person making $5000 (32% of poverty level) income would not be given a subsidy and a person making $50,000 per year would be given a $9,011 subsidy.
A person making $500,000 annually would not be given a subsidy ( go figure).
A proper system would provide an appropriate subsidy based upon actual income, so making only $5,000 annually should have resulted in a larger subsidy than the $9,011 offered during the calculation based upon $50,000 annual income.
The demonstrated Prejudicial pricing is just the tip of the iceberg.
There is no evidence that being poor makes you unwell, but certainly being unwell can make you poor.
Likewise, being wealthy won't necessarily make you well. If you have the wrong spiders for doctors , being wealthy can make you dead like Michael Jackson.
If forced into programs like the killing fields of medicaid which are designed to implement demise via structured neglect , the poor, disabled and elderly are going to the ovens.
Hello LVRJ Editor
There has been an insidious change in our society .
The sparse critical thinking that gave us an advantage in business and making proper personal choices has all but disappeared.
Watch television for a day and note how many advertisements there are for drugs . It is overwhelming, and many of the advertisements are for prescription medications, including "Ask your doctor" imperatives.
Recent media focus on tragic incidents of interpersonal violence have not addressed the root causes.
Most often, there are drugs involved and most often they are mood altering prescription medications taken by the perpetrators.
Homicide is only one of the consequences of people taking mood altering chemicals.
SSRI ingestion is very common and is associated with thousands of personal derailments including: bizarre behavior, aggression, suicide, homicide , kleptomania, assaults, hyper-sexuality and molestation.
Please look at this database of incidents involving these drugs, I am certain there are many more unreported.
Lets try to gather information and analyze it scientifically to see what the real problems are so that a rational response might result in proper corrective action.
Without proper information it is very unlikely to result in proper decisions.
Sam Wise MD
also visit this very interesting website about medication side-effects
Ask Dr. Wise: Over The Counter Medications - Our Reality Barriers Are Broken Down
What's more dangerous, a federally controlled narcotic or the ingredients commonly found in over the counter medications?
The answer is perhaps not as straightforward as you might think.
And if you live your life believing that others, including governmental agencies, are protecting you from harm, listen in to this segment of the Ask Dr. Wise show. You'll come away with a different perspective, one that could protect you and your family from potential harm.
Marketeers with multimillion dollar budgets working for global enterprises employ every conceivable proven trick in the book to promote and sell tons of over the counter products using puppets, cartoon characters and computer generated images.
They make these products appear to be so safe that we're inclined to bath in them...what could happen?
Listen in and find out.
Ask Dr. Wise: The Child of Carcinogenesis
Now playing at a theater near you....just in time for Halloween, The Child of Carcinogenesis!
No, sorry to say, this segment of the Ask Dr. Wise Radio Show is not the stuff of fiction. It's an in depth examination of one of the most widely used and controversial over the counter pharmaceutical products marketed in the United States and around the globe; acetaminophen.
Before you visit that corner drug store to pick up that well known over the counter cold remedy, cough suppressant or something to knock down that pesky fever, you owe it to yourself to listen in as Dr. Wise challenges us all to understand how products advertised to help us, hold the potential for doing us harm, serious harm, perhaps even death.
Some products mix it with alcohol and histamines....a witches brew.
Ask Dr. Wise: Blue Jeans, Arsenic and Corn Flakes
Walk down the isle of any major drug store and just take a look at the volume of 'over-the-counter' medications.
What's in these products? Do they work? Are they safe to use, or could they potentially cause serious and irreversible harm? But there's no way they could cause cancer....could they?
During this segment of the Ask Dr. Wise show, Dr. Samuel Wise M.D., extemporaneously takes us on a fascinating journey that begins in India with the ancient process that created the highly prized blue indigo dye, to the dawn of the chemical industry in the mid 1800's, to the formation of the Pure Food and Drug Act.
At the turn of the 20th century, a common accepted treatment for tuberculosis was to collapse one lung and then send the patient to a spa to breathe fresh country air and eat 'healthy' foods. So what were these foods that were considered healthy and fed to these patients? Dr. Wise provides a history lesson of the first 'fast food' inventors whose products were consumed by these patients. A hundred years later these early inventor's products are still with us today. Names we all know, names like Kellogg, Post and Graham.
And if you think that we're narcissistic today, and will try almost anything to make us more attractive, wait to you hear the story of the face cream women used to give them a nice milky complexion in the early 1900's.
Most importantly you'll learn the names of ingredients and compounds currently actively marketed to the public today, names like acetaminophen, understand what they are, how they work, and gain and acquire information that might just save your life.
Or perhaps don't listen in and just go ahead and take that pill. What could go wrong?
We hope you'll listen in, we know you'll be glad you did, and then visit the Ask Dr. Wise website, www.askdrwise.com, to listen to all of the doctor's educational and entertaining shows.
004 Ask Doctor Wise: The Current State of the Health Care System in America, Part Four of a Four Part Radio Interview with Dr. Samuel Wise, M.D.
Ask Doctor Wise: The Current State of the Health Care System in America, Part Four of a Four Part Radio Interview with Dr. Samuel Wise, M.D.
Are you ready for another dose of "Catalytic Conversation'?
This is the final segment of a special four part interview with Dr. Samuel Wise, M.D., from his Las Vegas office.
In this segment Dr. Wise again challenges us to open our minds and let a new thought drift in.
Toasters are a hot topic in this segment, no pun intended, as the doctor suggests we should choose a physician with at least as much care and research as we pick out a new toaster. But no worries, to find a new physician simply look in your health insurance manual. There they are, 'approved providers', and all you have to do is pick one. Is that really how we should pick a doctor….from a list of names?
If that subject doesn't get your attention, how about the good doctor's thoughts that perhaps going to visit our physician should be more like going to our veterinarian.
Intrigued, interested, then listen in. You’ll be glad you did.
Your comments to these broadcasts are solicited and to stay in touch with Dr. Wise sign up for his newsletter on the home page of his website, www.askdrwise.com.
003 Ask Doctor Wise: The Current State of the Health Care System in America, Part Three of a Four Part Radio Interview with Dr. Samuel Wise, M.D.
Ask Doctor Wise: The Current State of the Health Care System in America, Part Three of a Four Part Radio Interview with Dr. Samuel Wise, M.D.
Did the doctor just say what I thought he said...? Can he really say that...?
The answer is yes, and yes.
If this episode about the current state of our health care system with Dr. Samuel Wise doesn't get your attention, nothing will. The good doctor starts off discussing, as he puts it, "the united mission of greed" as he explores the world of health insurance, or perhaps more appropriately, sickness insurance.
If hearing terms like, 'monkeys flying out of your butt insurance', are too rich for you, then you may not wish to listen to this hard hitting and educational segment of the Ask Doctor Wise show. But that would be a real shame as you would also miss the doctors thoughts about creating a new virus.....the 'Honesty Virus.'
This is a knowledge-rich 25 minutes that all of us should have an opportunity to experience.
Don't forget to leave a comment and please, if you wish to stay in touch with Dr.Wise, sign up for his newsletter on his home page.
Watch out for those monkeys...!!!!!!
002 Ask Doctor Wise: The Current State of the Health Care System in America, Part Two of a Four Part Radio Interview with Dr. Samuel Wise, M.D.
Ask Doctor Wise: The Current State of the Health Care System in America, Part Two of a Four Part Radio Interview with Dr. Samuel Wise, M.D.
In this second of four interviews, Dr. Samuel Wise, provides a candid and thought provoking assessment of a system that appears designed for those who seek profit and where the patient is no longer the customer.
The doctor challenges us with an unvarnished examination of a medical system driven by greed and profit and promoted to the public using fear, creating systems that are designed, not by accident, to confuse.
Who is the customer? Why doesn't the health care industry publish 'actual costs' for services, and is there any hope, any possibility, that the health care industry can be re-professionalized?
Listen in as Dr. Wise takes us on a journey of exploration and discovery, exploring the workings of the health care industry and begin to understand the realities of the current system and what if anything can be done to reposition and reestablish the patient as the customer.
Your comments and thoughts to this program are solicited and appreciated.